Italian validation of the 12item multiple sclerosis. Crosssectional msws 12 to eq5d cross walking analysis. The methods used to assess walking ability vary widely between treatment centres, and the accuracy of the methods used and numbers of parameters determined. We sought to evaluate the effect of dalfampridineer tablets prolongedrelease fampridine in europe on health utility in patients with multiple sclerosis ms by mapping subjects individual item scores from the 12item multiple sclerosis walking scale msws12 onto the euroqol 5dimension eq5d health utility index. Mapping from the multiple sclerosis walking scale msws12.
Pdf mapping of multiple sclerosis walking scale msws12 to. Value of gait analysis for measuring disease severity using. Mapping the 12item multiple sclerosis walking scale to. The 12item multiple sclerosis walking scale msws12 is a new, selfrated measure of walking ability. Mapping the 12item multiple sclerosis walking scale to the. Their findings suggest that walking function at baseline 6mwt and t25wt accurately predicts the responder status. Multiple sclerosis impact scale msis29 the following questions ask for your views about the impact of ms on your daytoday life during the past two weeks for each statement, please circle the one number that best describes your situation please answer all questions in the past two weeks. Psychometric performance of a generic walking scale walk12g. The patient determined disease steps pdds is a promising patientreported outcome pro of disability in multiple sclerosis ms. The ashworth rates tone on a scale of 04, while the modified ashworth was developed to further define the lower end of the scale making it more discrete by adding. Home for professionals researchers resources for researchers clinical study measures ambulation index ai share this page facebook twitter email. The 12item multiple sclerosis walking scale msws12 is a patientreported outcome instrument that quantifies the progressive loss of walking ability from the patient perspective. An exemplar using the 12item multiple sclerosis walking scale.
Jun 26, 20 we sought to evaluate the effect of dalfampridineer tablets prolongedrelease fampridine in europe on health utility in patients with multiple sclerosis ms by mapping subjects individual item scores from the 12item multiple sclerosis walking scale msws12 onto the euroqol 5dimension eq5d health utility index. The effects of exergaming on balance, gait, technology. Impact of walking impairment in multiple sclerosis. The msw12 questionnaire is designed to measure how multiple sclerosis has affected the individuals walking ability. The 12item multiple sclerosis walking scale msws12 can help you find out. Multiple sclerosis walking scale12 and oxygen cost of. The 12item multiple sclerosis walking scale msws12 is a selfreport. Impact of nutritional intake on function in people with. A change will be indicated by a reduction or increase.
Jrrd volume 49, number 3, 2012 pages 467476 accelerometer output and its association with energy expenditure in persons with multiple sclerosis. Walking impairment has a major influence on the qualityoflife of people with multiple sclerosis ms. One hundred fortynine patients in the community and 53 hospital outpatients with ms completed the msws12 and other outcome measures. Filli and collaborates tested the predictive value of a set of demographic and clinical criteria including t25wt, walking endurance 6min walk test 6mwt, and the 12 item multiple sclerosis walking scale msws 12.
Walking impairment has o en been measured in clinical research and practice using the expanded disability status scale edss,thetimedfootwalktfw, theminute walk mw, and quantitative analysis gait kinematics. An equation for mapping the msws12 to the eq5d was previously developed and validated using a north american research committee on. T25fw, the dynamic gait index dgi, the 12item ms walking scale msws12 and the timed up and go test tugt. The dynamic gait index and the timed up and go test involve other aspects of mobility, including balance.
Self reported walking ability was measured using the multiple sclerosis walking scale 12 msws 12. Mos pain effects scale pes multiple sclerosis functional composite msfc multiple sclerosis quality of life54 msqol54. Msws12 is a patientrated measure of walking quality. Brain sciences free fulltext cortical excitability.
Sep 23, 2015 the 12item multiple sclerosis walking scale msws 12 is a patientreported outcome that assesses the impact of walking impairment in people with ms. Subjects also completed two selfreport assessment questionnaires. Hobart jc, riazi a, lamping dl, fitzpatrick r, thompson aj. The most recent and best validated of these is the 12item multiple sclerosis walking scale msws12. The 12item multiple sclerosis walking scale msws12 is a. Of the instruments available, the clinicianobserved timed 25foot walk and patient selfreport 12item multiple sclerosis walking scale have properties that make them suitable for routine evaluation of walking performance. Gait impairment is commonly in people with multiple sclerosis ms. Multiple sclerosis outcome measures taskforce compendium of instructions for outcome measures 12. Objective to map the 12item multiple sclerosis walking scale msws12 onto. Profile, ms multiple sclerosis, msws 12 12 item multiple sclerosis walking scale, mvpa moderatetovigorous physical activity, pdds patientdetermined disease steps, sd standard deviation, vo2 rate of oxygen consumption. Evaluating walking in patients with multiple sclerosis. Six ms outpatient clinics across italy enrolled subjects. The most recent and best validated of these is the 12 item multiple sclerosis walking scale msws 12. Preliminary psychometric evaluation data quality, scaling assumptions, acceptability, reliability, validity was undertaken in the data.
Its clinical benefits are assessed by timed and subjective tests, such as the 12item ms walking scale msws12. Altered gait is one of the most common symptoms of multiple sclerosis. In a version 2, three items are scored, and nine items are. Gait dysfunction is a common and relevant symptom in multiple sclerosis ms. The 12item multiple sclerosis walking scale msws12 is a validated rating scale that captures patients perceptions of the impact of ms on walking ability 4. Ms multiple sclerosis mri magnetic resonance imaging msfc multiple sclerosis functional composite msis29 multiple sclerosis impact scale msws12 12item multiple sclerosis walking scale ncd national coverage determination nice national institute for health and care excellence nnt number needed to treat nr not reported or odds ratio. The walk12g was adapted from the 12item multiple sclerosis walking scale as.
The 12item multiple sclerosis walking scale msws12 is a selfreport measure of the impact of ms on. Confirming the validity and responsiveness of the multiple. Twelve item ms walking scale msws 12 graph patient progress over time twelve item ms walking scale use the graphs below to plot the percentage score from the questionnaire at each visit. Full text mapping of multiple sclerosis walking scale msws. Profiling walking dysfunction in multiple sclerosis. Twelve item ms walking scale msws12 sailing sclerosis. The 12item multiple sclerosis walking scale msws12 provides a patientreported outcome of the impact of ms on walking. Measuring the impact of ms on walking ability neurology. Crosssectional msws12 to eq5d cross walking analysis.
Siponimod for the treatment of secondary progressive multiple. The msws12 is a standardized tool that many healthcare professionals use to. A recent study confirmed the association between msws 12 scores and t25fw and 6mw performance and showed the association between msws 12 scores and spatial and temporal parameters of gait. The original scoring provides options 15 for each item, with 1 meaning no limitation and 5 meaning extreme limitation on the gaitrelated item.
Multiple sclerosis the 12item multiple sclerosis walking scale msws 12 involves the damage to your email box. Then a few minutes are needed to establish the ratings in the edss scale. Italian validation of the 12item multiple sclerosis walking. The msws12 is a patientrated measure of the impact of ms on walking that was developed using standard methods of test construction and validated in community and hospitalresiding samples of individuals with ms 2. It is a less sensitive measure of other types of multiple sclerosis disability. Many other disabling neurological conditions affect patients ability to walk, and a generic measure of walking could provide valuable insights into patients perceptions in clinical trials and epidemiological studies as well as routine clinical practice. The multiple sclerosis walking scale 12item msws12 is a pro measure that is widely used to address this need.
Validation of patient determined disease steps pdds scale. This study aimed to profile gait pathology in gaitimpaired patients with ms using comprehensive 3d. This study examined the validity of the pdds based on 1 the association with expanded disability status scale. A manufacturersponsored study has suggested the minimal clinically important difference on the msws12 to be 6. Its clinical benefits are assessed by timed and subjective tests, such as the 12 item ms walking scale msws 12. The 12item multiple sclerosis walking scale msws12 is a selfreport measure of the impact of ms on the individuals walking ability. Multiple sclerosis abstract walking ability is a vital component of validated test procedures to assess mobility impairment in multiple sclerosis ms. The aim of this study was to crossculturally adapt and validate the msws12 for the italian population with ms. Crosscultural adaptation and validation of the 12item. Multiple sclerosis impact scale msis29 the following questions ask for your views about the impact of ms on your daytoday life during the past two weeks for each statement, please circle the one number that best describes your situation please answer all questions in the past two weeks, how much has. Patientreported outcomes are also useful to inform disease severity. These test methods require minimal equipment to perform such as a stopwatch. Development of a gait module to complement the 12item. Multiple sclerosis walking scale 12 items eeducation eurims.
To develop a patientbased measure of walking ability in ms. Full text mapping of multiple sclerosis walking scale. Units technical support document for using mapping methods to estimate. The multiple sclerosis walking scale is a selfassessment scale which measures the impact of ms on walking. Data are lacking on the impact of these impairments from the perspectives of people with ms and care partners of a person with ms, defined as individuals caring for a friend or family member with ms. Pdf testing patientreported outcome measurement equivalence. The multiple sclerosis walking scale msws12 assesses the impact of ms on walking ability from the patients perspective, but in its current form, is not amenable for use in many policy decision making settings. Original research paper development of a gait module to. Mapping the 12 item multiple sclerosis walking scale to the. Total scores range from 0 to 100, and larger scores indicate greater impact of ms on a patients ability to walk. Testing patientreported outcome measurement equivalence in multinational clinical trials. However, previous psychometric analyses indicated floor and ceiling effects across the multiple sclerosis severity spectrum. It consists of 12 questions concerning the limitations to walking due to ms during the past 2 weeks. Siponimod for the treatment of secondary progressive.
The impact of ms on walking was assessed by the 12item multiple sclerosis walking scale msws12 questionnaire, the expanded disability status scale score, and by clinical test with the time to be ready to void trv. The 12item multiple sclerosis walking scale msws12 is a patientreported questionnaire. Evaluate the efficacy and safety of ads5102 in ms patients with walking impairment as measured by timed 25foot walk t25w, timed up and go tug, 2minute walk test 2mwt, and the 12item multiple sclerosis walking scale msws12. To date, there is limited evidence regarding the validity of pdds scores, despite its sound conceptual development and broad inclusion in ms research. Fear of falling was assessed by a simple question and with falls efficacy scale international fesi questionnaire.
To map the 12item multiple sclerosis walking scale msws12 onto the euroqol 5dimension eq5d healthutility index in multiple sclerosis ms patients participating in the north american research committee on multiple sclerosis narcoms registry. University of illinois at urbanachampaign, department of. Mapping the 12item multiple sclerosis walking scale to the euroqol. Multiple sclerosis outcome measures taskforce compendium of.
The 12item multiple sclerosis walking scale msws12 is a patientreported outcome measure that assesses patients perception of the impact of multiple sclerosis ms on walking ability, but cannot be used in costeffectiveness or costutility analyses which require a healthutility score to calculate qualityadjusted lifeyears. Msws12 scores are generated by summing the scores from all items, subtracting the minimum score 12, dividing by the maximum score 48, and then. The 12item ms walking scale msws12 assesses patients measurement of walking quality. The msws12 was used as to validate the clinical significance of changes in walking speed as measured by the timed 25foot walk t25fw in a phase 3 randomized, con. However, previous psychometric analyses indicated floor and ceiling effects across the multiple sclerosis. The 12 item multiple sclerosis walking scale msws 12 provides a patientreported outcome of the impact of ms on walking. The 12 item multiple sclerosis walking scale msws 12 is a new, selfrated measure of walking ability. To map the 12 item multiple sclerosis walking scale msws 12 onto the euroqol 5dimension eq5d healthutility index in multiple sclerosis ms patients participating in the north american research committee on multiple sclerosis narcoms registry. Improvement is indicated by negative change scores. Ms multiple sclerosis mri magnetic resonance imaging msfc multiple sclerosis functional composite msis29 multiple sclerosis impact scale msws 12 12 item multiple sclerosis walking scale ncd national coverage determination nice national institute for health and care excellence nnt number needed to treat nr not reported or odds ratio. The multiple sclerosis walking scale msws 12 was developed to measure the impact of multiple sclerosis on walking.
The 12 item multiple sclerosis walking scale 12 msws is a validated questionnaire which assessed walking function. The scale has not been independently validated for use in differing ms populations. Each item can be answered with 5 options, with 1 meaning no limitation and 5 extreme limitation. Mapping of multiple sclerosis walking scale msws12 to five.
A recent study confirmed the association between msws12 scores and t25fw and 6mw performance and showed the association between msws12 scores and spatial and temporal parameters of gait. Multiple sclerosis walking scale 12 msws12 time frame. Jun 18, 2012 in developing the patientslikeme online platform for patients with multiple sclerosis ms, we required a patientreported assessment of functional status that was easy to complete and identified disability in domains other than walking. Research article italian validation of the 12item multiple. Safety and efficacy of ads5102 in multiple sclerosis. Gait impairment is reported by 85% of patients with multiple sclerosis ms as main complaint. Instrumented balance and walking assessments in persons with. May 18, 20 the 12item multiple sclerosis walking scale msws12 is a patientreported outcome measure that assesses patients perception of the impact of multiple sclerosis ms on walking ability, but cannot be used in costeffectiveness or costutility analyses which require a healthutility score to calculate qualityadjusted lifeyears. The 12item multiple sclerosis walking scale msws12 is a patientreported outcome that assesses the impact of walking impairment in people with ms.
Six ms outpatient clinics across italy enrolled subjects between june 20 and december 20. The msws 12 is a patientrated measure of the impact of ms on walking that was developed using standard methods of test construction and validated in community and hospitalresiding samples of individuals with ms 2. The functional independence measure fim the 12item multiple sclerosis walking scale msws12 the modified fatigue impact scale mfis fatigue severity scale fss multiple sclerosis quality of life54 instrument msqol54 multiple sclerosis impact scale msis29. The 12item multiple sclerosis walking scale msws 12 is a patientreported outcome that assesses the impact of walking impairment in people with ms. Further validation of multiple sclerosis walking scale12 scores. Existing measures of functional status were inadequate, clinicianreported, focused on walking, and burdensome to complete. An equation for mapping the msws 12 to the eq5d was previously developed and validated using a north american research committee on ms narcoms registry cohort. Multiple sclerosis ms is the most common neurological disorder in young adults. Higher scores indicate a greater impact on walking than lower scores. Research article italian validation of the 12item multiple sclerosis walking scale c.
One hundred fortynine patients in the community and 53 hospital outpatients with ms completed the msws 12 and other outcome measures. For example, in a previous project that aimed to improve targeting of the 12item multiple sclerosis walking scale for higher functioning multiple sclerosis patients, a gait module was developed. Confirming the validity and responsiveness of the multiple sclerosis. Feb 03, 2016 the 12 item multiple sclerosis walking scale msws 12 is a patientreported outcome that assesses the impact of walking impairment in people with ms. Is the severity of urinary disorders related to falls in. Mapping of multiple sclerosis walking scale msws12 to. Estimation of the effect of dalfampridineer on health. The higher the scorepercentage, the greater the perceived impact ms is having on walking ability. Pdf development of a gait module to complement the 12.
364 966 530 368 1529 1210 34 110 450 362 35 1226 500 173 1399 1641 1562 959 1145 530 1038 26 1121 1409 835 1504 34 579 579 55 1011 1191 298 359 1230 108 948 1415 278 507 1051 1291 1092 1068